Anti-Desmoglein 2 / DSG2, clone 6D8

Anti-Desmoglein 2 / DSG2, clone 6D8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3289-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3289-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Recognizes a protein... more
Product information "Anti-Desmoglein 2 / DSG2, clone 6D8"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Recognizes a protein of 165kDa, identified as Desmoglein-2 (DSG2). This monoclonal antibody recognizes the extracellular domain of human desmoglein-2. Desmoglein-2 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, desmogleins have R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tails of desmogleins interact with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the desmogleins with the intermediate filaments. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. Desmoglein2 was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon). Protein function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [The UniProt Consortium]
Keywords: Anti-HDGC, Anti-DSG2, Anti-CDHF5, Anti-Desmoglein-2, Anti-Cadherin family member 5, Desmoglein 2 Antibody / DSG2
Supplier: NSJ Bioreagents
Supplier-Nr: V3289-20UG

Properties

Application: FC, IF, IP, WB
Antibody Type: Monoclonal
Clone: 6D8
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A recombinant human DSG2 protein was used as the immunogen for the Desmoglein 2 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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