Anti-Desmocollin 2/3, clone 7G6

Anti-Desmocollin 2/3, clone 7G6
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3268SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Desmosomes are intercellular adhering junctions... more
Product information "Anti-Desmocollin 2/3, clone 7G6"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of Desmocollin-2 varies in the basal and suprabasal layers. And Desmocollin-3 is expressed more evenly throughout the suprabasal layers. Protein function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [The UniProt Consortium]
Keywords: Anti-DSC2, Anti-CDHF2, Anti-Desmocollin-3, Anti-Desmocollin-2, Anti-Cadherin family member 2, Anti-Desmosomal glycoprotein II, Anti-Desmosomal glycoprotein III, Desmocollin 2/3 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3268SAF-100UG

Properties

Application: WB, FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: 7G6
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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