Anti-Desmin (Muscle cell marker), clone DES/1711

Anti-Desmin (Muscle cell marker), clone DES/1711
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3195SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Cytoskeletal intermediate filaments (IFs)... more
Product information "Anti-Desmin (Muscle cell marker), clone DES/1711"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. Protein function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. [The UniProt Consortium]
Keywords: Anti-DES, Anti-Desmin, Desmin Antibody (Muscle cell marker)
Supplier: NSJ Bioreagents
Supplier-Nr: V3195SAF-100UG

Properties

Application: WB, FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: DES/1711
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat, Hamster, Chicken
Immunogen: Recombinant human Desmin was used as the immunogen for the Desmin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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