Anti-DENND1B

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA042586.25	25 µl		-		3 - 8 business days*		369.00€
ATA-HPA042586.100	100 µl		-		3 - 8 business days*		491.00€

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Protein function: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of... more

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Product information "Anti-DENND1B"

Protein function: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 66% and to rat: 67%

Keywords:	Anti-Connecdenn 2, Anti-Protein FAM31B, Anti-DENN domain-containing protein 1B
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA042586

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: AFLCGGSGDQ AEWNLGQDDS ALHGKHLPPS PRKRVSSSGL TDSLFILKEE NSNKHLGADN VSDPTSGLDF QLTSPEVSQT D (ATA-APrEST83637)