Anti-DDX1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ATA-HPA034503.25 25 µl -

7 - 10 business days*

335.00€
ATA-HPA034503.100 100 µl -

7 - 10 business days*

446.00€
 
Protein function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA... more
Product information "Anti-DDX1"
Protein function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 98% and to rat: 98%
Keywords: Anti-DDX1, Anti-DBP-RB, Anti-DEAD box protein 1, Anti-DEAD box protein retinoblastoma, Anti-ATP-dependent RNA helicase DDX1
Supplier: Atlas Antibodies
Supplier-Nr: HPA034503

Properties

Application: WB, IHC, ICC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LGKSHIRTDD VHAKDNTRPG ANSPEMWSEA IKILKGEYAV RAIKEHKMDQ AIIFCRTKID CDNLEQYFIQ QGGGPDKKGH QFSCVCLHGD (ATA-APrEST78944)

Database Information

KEGG ID : K13177 | Matching products
UniProt ID : Q92499 | Matching products
Gene ID : GeneID 1653 | Matching products
Protein Atlas Nr. : ENSG00000079785

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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