Anti-DCUN1D1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA035911.100	100 µl		-		3 - 8 business days*		491.00€

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Protein function: Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954).... more

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Product information "Anti-DCUN1D1"

Protein function: Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 98% and to rat: 100%

Keywords:	Anti-DCNL1, Anti-DCN1-like protein 1, Anti-DCUN1 domain-containing protein 1, Anti-Squamous cell carcinoma-related oncogene, Anti-Defective in cullin neddylation protein 1-like protein 1
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA035911

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: RQFMIFTQSS EKTAVSCLSQ NDWKLDVATD NFFQNPELYI RESVKGSLDR KKLEQLYNR (ATA-APrEST79283)