Anti-DcR2

Anti-DcR2 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with DcR2 with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with DcR2 from other sources has not been determined. DcR2 antibody detects human DcR2 precursor. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. Anti-DcR2 antibodies are ideal for investigators involved in NFkappaB, Apoptosis, Cytokine and Growth factor research.