Anti-DAND5 (DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO

DAND5, also known as COCO, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN, Gremlin, PRDC, and Cerberus. DAND5 binds and inhibits Xnr1, BMP-4, Activin, and Wnt8. It is implicated in gastrulation and embryonic left-right axis formation. Human DAND5 shares 60% and 24% aa sequence identity with mouse and Xenopus DAND5, respectively. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA (Detection): 0.5-2ug/ml, Optimal dilutions to be determined by the researcher. Matched Pair: Capture: D1038-08A, Detection: D1038-08, Hybridoma: Mouse myeloma cells with B cells obtained from a mouse immunized with purified, E.coli- derived, recombinant human DAND5 (aa23-189). Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.