Anti-Cytomegalovirus pp65 (CMV-pp65), recombinant antibody, clone rCMV/12688

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Host cytoplasm, Host nucleus, Virion tegument. Positive Control: CMV-infected cells. CMV-infected tissues. Protein Function: Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932) [The Uniprot Consortium]