Anti-Cytokeratin PE (Clone C-11)

Cytokeratins (CKs) are intermediate filaments proteins and members of the cytokeratin protein family. The cytokeratin family is composed of at least 20 unique gene products, which fall into two categories: type I acidic cytokeratins, CK9-CK20, and type II neutral-basic cytokeratins, CK1-CK8. Each cytokeratin is composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratins are major structural proteins expressed in epithelial cells and localized to the cytoplasm where they form heterozygous type I-type II pairs. They primarily function to protect epithelial cells from mechanical and non-mechanical stresses that induce cell rupture and death. Cytokeratins have additional isoform- and tissue-specific functions, including the modulation of protein synthesis and cell size during epithelial growth and roles in skin pigmentation. Cayman's Cytokeratin Monoclonal PE Antibody (Clone C-11) can be used for flow cytometry (FC) and immunofluorescence (IF) applications. This antibody recognizes cytokeratins 4, 5, 6, 8, 10, 13, and 18 from human samples.Synonyms: CKs, pan-Cytokeratin, Keratin. Clone Designation: C-11. Formulation: (Request formulation change), 100 µg of protein A-purified, PE-labeled monoclonal antibody. Storage Buffer: 100 mM sodium phosphate, pH 7.4, with 50 mM sucrose, 150 mM sodium chloride, 0.1% BSA, and 2 mM sodium azide when reconstituted in 1 ml double distilled water. Host: Mouse. Isotype: IgG1. Applications: FC, IF. Cross Reactivity: (+) Cytokeratin 4, (+) Cytokeratin 5, (+) Cytokeratin 6, (+) Cytokeratin 8, (+) Cytokeratin 10, (+) Cytokeratin 13, (+) Cytokeratin 18.