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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2171SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. Cytokeratin 8 is the product of the KRT8... more
Product information "Anti-Cytokeratin 8, clone TS1"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Cytokeratin 8 is the product of the KRT8 gene and one of the most abundant keratins. The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Cytokeratin 8 participates in cellular differentiation and signal transduction, protects against apoptosis, stress and injury, and helps maintain cellular structural integrity. It is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Specific combinations of cytokeratins are associated with certain epithelial cells, and therefore useful in the characterization of poorly differentiated carcinoma. Hepatocellular carcinomas are defined by the use of antibody that recognizes only cytokeratin 8 and 18. Keratin 8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Antibody to Cytokeratin 8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against Keratin 8, 18 and 19). Reportedly, Cytokeratin 8 antibody is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast. Protein function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. [The UniProt Consortium]
Keywords: | Anti-K8, Anti-CK-8, Anti-KRT8, Anti-CYK8, Anti-Keratin-8, Anti-Cytokeratin-8, Anti-Type-II keratin Kb8, Anti-Keratin, type II cytoskeletal 8, Cytokeratin 8 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2171SAF |
Properties
Application: | FC, IHC, IF |
Antibody Type: | Monoclonal |
Clone: | TS1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Keratin preparation from a human carcinoma was used as the immunogen for this Cytokeratin 8 antibody. The epitope of the TS1 mAb has been determined to be within amino acids 343-357. |
Format: | Purified |
Database Information
KEGG ID : | K07605 | Matching products |
UniProt ID : | P05787 | Matching products |
Gene ID | GeneID 3856 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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Discount Promotion
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Discount Promotion
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