Anti-Cyclin D1 (PRAD-1, bcl-1)

Anti-Cyclin D1 (PRAD-1, bcl-1)
Anti-Cyclin D1 (PRAD-1, bcl-1)
   
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-153 100 µl - -

3 - 9 business days*

506.00€
 
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and... more
Product information "Anti-Cyclin D1 (PRAD-1, bcl-1)"
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]
Keywords: Anti-BCL1, Anti-BCL-1, Anti-CCND1, Anti-BCL-1 oncogene, Anti-PRAD1 oncogene, Anti-G1/S-specific cyclin-D1, Anti-B-cell lymphoma 1 protein
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-153

Properties

Application: ELISA, WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Rat, Mouse (Expected: Chimpanzee, Orangutan, Dog, Chicken, Zebrafish, Frog)
Immunogen: full length synthetic polypeptide corresponding to the human gene sequence
MW: 34 kD
Format: Serum

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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