Anti-Cyclin D1 (PRAD-1, bcl-1)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-153 100 µl - -

6 - 10 business days*

684.00€
 
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and... more
Product information "Anti-Cyclin D1 (PRAD-1, bcl-1)"
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]
Keywords: Anti-BCL1, Anti-BCL-1, Anti-CCND1, Anti-BCL-1 oncogene, Anti-PRAD1 oncogene, Anti-G1/S-specific cyclin-D1, Anti-B-cell lymphoma 1 protein
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-153

Properties

Application: ELISA, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat, mouse (Expected: chimpanzee, orangutan, dog, chicken, zebrafish, frog)
Immunogen: full length synthetic polypeptide corresponding to the human gene sequence
MW: 34 kD
Format: Serum

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Cyclin D1 (PRAD-1, bcl-1)"
Write a review
or to review a product.
Viewed