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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| 100-401-153 | 100 µl | - | - |
6 - 10 business days* |
719.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and... more
Product information "Anti-Cyclin D1 (PRAD-1, bcl-1)"
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]
| Keywords: | Anti-BCL1, Anti-BCL-1, Anti-CCND1, Anti-BCL-1 oncogene, Anti-PRAD1 oncogene, Anti-G1/S-specific cyclin-D1, Anti-B-cell lymphoma 1 protein |
| Supplier: | Rockland Immunochemicals |
| Supplier-Nr: | 100-401-153 |
Properties
| Application: | ELISA, IP, WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, rat, mouse (Expected: chimpanzee, orangutan, dog, chicken, zebrafish, frog) |
| Immunogen: | full length synthetic polypeptide corresponding to the human gene sequence |
| MW: | 34 kD |
| Format: | Serum |
Database Information
| KEGG ID : | K04503 | Matching products |
| UniProt ID : | P24385 | Matching products |
| Gene ID : | GeneID 595 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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