Anti-Cyclin B1, clone BCLB1-1

Anti-Cyclin B1, clone BCLB1-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7161SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Cyclin B1 (CCNB1) is a regulatory protein... more
Product information "Anti-Cyclin B1, clone BCLB1-1"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis. The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. Its activation is well-regulated, and positive feedback loops ensure that once the CCNB1-Cdk1 complex is activated, it is not deactivated. CCNB1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation, nuclear envelope breakdown, and spindle pole assembly. Once activated, CCNB1-Cdk1 promotes several of the events of early mitosis. The active complex phosphorylates and activates 13S condensin, which helps to condense chromosomes. Another important function of the complex is to break down the nuclear envelope. The nuclear envelope is a membranous structure containing large protein complexes supported by a network of nuclear lamins. Phosphorylation of the lamins by CCBN1-Cdk1 causes them to dissociate, compromising the structural integrity of the nuclear envelope so that it breaks down. The destruction of the nuclear envelope is important because it allows the mitotic spindle to access the chromosomes. [Wiki] Protein function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. [The UniProt Consortium]
Keywords: Anti-CCNB, Anti-CCNB1, Anti-G2/mitotic-specific cyclin-B1, Cyclin B1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7161SAF

Properties

Application: IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: BCLB1-1
Conjugate: No
Host: Mouse
Species reactivity: human, mouse
Immunogen: Recombinant human full-length protein was used as the immunogen for the Cyclin B1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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