Anti-Cyclin B1 (CCNB1), clone SPM619

Anti-Cyclin B1 (CCNB1), clone SPM619
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2947IHC-7ML 7 ml - -

3 - 10 business days

Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. It... more
Product information "Anti-Cyclin B1 (CCNB1), clone SPM619"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition. Protein function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. [The UniProt Consortium]
Keywords: Anti-CCNB, Anti-CCNB1, Anti-G2/mitotic-specific cyclin-B1, Cyclin B1 Antibody (CCNB1)
Supplier: NSJ Bioreagents
Supplier-Nr: V2947IHC-7ML


Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM619
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: Recombinant human full-length CCNB1 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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