Anti-CXCR5 / C-X-C motif chemokine receptor 5, clone CXCR5/13100

1 mg/ml in 1X PBS, BSA free, sodium azide free. Burkitt Lymphoma Receptor 1 antibody, also known as CXCR5 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as CD185. Burkitt Lymphoma Receptor 1 is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it regulates chemokine-directed cell migration. As a member of the CXC chemokine receptor family, CXCR5 binds the ligand CXCL13 and plays a central role in lymphoid follicle organization and germinal center formation.Burkitt Lymphoma Receptor 1 antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular regions responsible for ligand binding, and intracellular domains that couple to heterotrimeric G proteins. Upon binding CXCL13, CXCR5 activates downstream signaling pathways that promote cytoskeletal rearrangement and directed chemotaxis. Through these mechanisms, CD185 directs B cells and T follicular helper cells into B cell follicles within secondary lymphoid tissues, supporting adaptive immune responses and antibody affinity maturation.Functionally, CXCR5 is essential for humoral immunity and proper germinal center architecture. Expression of Burkitt Lymphoma Receptor 1 defines follicular B cells and T follicular helper cells and is widely used as a marker in immunophenotyping studies. Dysregulated CXCR5 signaling has been implicated in autoimmune diseases, chronic inflammatory disorders, and lymphoid malignancies. In certain B cell lymphomas, altered CXCR5 expression may influence tumor cell localization and interaction with the lymphoid microenvironment.The CXCR5 gene is located on chromosome 11 and is transcriptionally regulated during lymphocyte activation and differentiation. Because Burkitt Lymphoma Receptor 1 expression is largely restricted to defined immune cell subsets, detection of this receptor provides insight into lymphocyte trafficking, germinal center dynamics, and immune cell compartmentalization within tissues.The Burkitt Lymphoma Receptor 1 antibody (clone CXCR5/13100) is suitable for detecting CXCR5 protein expression in research applications. This CXCR5 antibody supports investigation of B cell biology, T follicular helper cell function, lymphoid tissue organization, and immune-mediated disease mechanisms.