Anti-CXCL10 (canine)

The Canine CXCL10 (IP-10) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Canine CXCL10 ELISA. The Canine CXCL10 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CXCL10 - None) (Canine CXCL10 - Strong) (Caprine CXCL10 - None) (Cynomolgus Monkey CXCL10 - None) (Dolphin CXCL10 - None) (Equine CXCL10 - Weak) (Feline CXCL10 - Moderate) (Guinea Pig CXCL10 - None) (Human CXCL10 - None) (Mouse CXCL10 - Moderate) (Ovine CXCL10 - None) (Rabbit CXCL10 - Moderate) (Rat CXCL10 - None) (Swine CXCL10 - Strong). For research use only. Made in the USA Protein function: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. [The UniProt Consortium]