Anti-CXCL1 (C-X-C motif chemokine 1, GRO-alpha(1-73), Melanoma growth stimulatory activity)

CXCL1(Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a , small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, , GROalpha, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha , (MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on , 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in , melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and , has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the , migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,, wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor , migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected , enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially , regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis , signature genes identified, several, including CXCL1, were functionally validated. UniProt Number: P09341, Gene ID: CXCL1, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.