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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R31094 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CREB-Regulated Transcription Coactivator... more
Product information "Anti-CRTC2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CREB-Regulated Transcription Coactivator 2, also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al.(2003) found that it potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al.(2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al.(2009) found that the protein functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals. Protein function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). [The UniProt Consortium]
Keywords: | Anti-TORC2, Anti-CRTC2, Anti-TORC-2, Anti-Transducer of CREB protein 2, Anti-CREB-regulated transcription coactivator 2, Anti-Transducer of regulated cAMP response element-binding protein 2, CRTC2 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R31094 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | An amino acid sequence from the C-terminus of human CRTC2 (QDPHTFNHQNLTHCSRH) was used as the immunogen for this CRTC2 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K16333 | Matching products |
UniProt ID : | Q53ET0 | Matching products |
Gene ID | GeneID 200186 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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