Anti-Crossveinless 2 (CV2, CV-2, CRIM3, BMP-Binding Endothelial Regulator Protein Precursor, BMPER2)

Crossveinless-2 (CV-2), also known as BMPER2 (BMP-binding endothelial regulator), is a secreted glycoprotein that contains a trypsin-inhibitory like domain, five cysteine-rich domains, and a von Willebrand factor type D domain. CV-2 modulates the activity of BMP-2 and BMP-4 in neural crest migration and osteoblast and chondrocyte differentiation. During zebrafish gastrulation, CV-2 is proteolytically cleaved to generate a BMP agonist from a BMP antagonist. Mature human and mouse CV-2 share 93% aa sequence identity. Applications: Suitable for use in Western Blot and ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.