Anti-Crmp4 / Dpysl3 / Drp-3

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Dihydropyrimidinase-related protein 3 is an enzyme that in humans is encoded by the DPYSL3 gene. This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. Protein function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. [The UniProt Consortium]