Protein function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. [The UniProt Consortium]
Human, Mouse (Expected: Rat, X. Laevis, X. Tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, West Indian Ocean Coelacanth, Duckbill Platypus, Spotted Green Pufferfish)
synthetic peptide. The epitope recognized by IHC-00267 maps to a region between residue 501 and 551 of human cleavage and polyadenylation specific factor 6, 68kDa using the numbering given in entry NP_008938.1 (GeneID 11052).