Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. [The UniProt Consortium]
Human, Mouse (Expected: Rat, Bovine, Dog, Horse, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, White-tufted-ear Marmoset, African Elephant, Chinese Hamster, Naked Mole Rat, Small-eared Galago)
synthetic peptide. The epitope recognized by IHC-00306 maps to a region between residue 1392 and 1442 of human cleavage and polyadenylation specific factor 1, 160kD subunit using the numbering given in entry NP_037423.1 (GeneID 29894).