Anti-Connexin 43

Anti-Connexin 43 antibody is directed against rat Connexin 43. Anti-Connexin 43 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Anti-Connexin 43 antibody recognizes Connexin 43 from rat sources. Cross reactivity with Connexin 43 from other species has not been determined. However, reactivity is also expected from the following species based on 100% sequence homology: chicken, canine, finch, human, mouse, NHP, sheep, Xenopus and zebra fish. Protein function: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. [The UniProt Consortium]