Anti-Collagen XI alpha1

collagen type XI alpha 1 chain(COL11A1) Homo sapiens This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009], Protein function: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000, ELISA 1:10000-20000. Cellular localization: Secreted, extracellular space, extracellular matrix .