Anti-Collagen IV/COL4A1 Picoband(TM)

Store at -20 °C for one year from date of receipt. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for six months. Avoid repeated freeze-thaw cycles.BackgroundSubcellular LocalizationType IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. Tissue Specificity: Basement membrane.