Anti-Clusterin / Apolipoprotein J, clone r7D1

1 mg/ml in 1X PBS, BSA free, sodium azide free. Apolipoprotein J antibody targets Apolipoprotein J, a multifunctional glycoprotein encoded by the CLU gene that is also widely known as Clusterin and ApoJ. Apolipoprotein J functions as an extracellular and intracellular molecular chaperone involved in protein quality control, lipid transport, and cellular stress responses. The protein is expressed in a broad range of tissues, including brain, adrenal gland, kidney, liver, reproductive organs, and epithelial tissues, and can localize to the cytoplasm, nucleus, cell surface, or extracellular space depending on cellular context. Apolipoprotein J antibody is frequently used in research focused on cellular stress pathways, protein homeostasis, and tissue injury responses.Apolipoprotein J exists in multiple isoforms generated through alternative splicing and post-translational processing, resulting in both secreted and intracellular forms with distinct biological roles. The secreted form, often referred to as apolipoprotein J or ApoJ, is associated with lipid transport and extracellular chaperone activity, while intracellular Clusterin has been implicated in apoptosis regulation, DNA damage responses, and cell survival signaling. In the nervous system, Apolipoprotein J expression has been linked to synaptic maintenance and neuroprotection, whereas in endocrine and epithelial tissues it is often associated with differentiation and secretory activity. Clone r7D1 is designed to recognize Apolipoprotein J for research use in studies examining CLU and ApoJ expression and subcellular distribution.Altered Apolipoprotein J expression has been reported in a variety of pathological conditions, including neurodegenerative disorders, cardiovascular disease, inflammation, and cancer. In oncology research, CLU and ApoJ have been investigated for associations with tumor progression, therapy resistance, and cellular adaptation to stress. Changes in Apolipoprotein J expression have also been linked to tissue remodeling and injury responses in organs such as the brain and kidney. Clone r7D1 provides a tool for examining Apolipoprotein J expression and distribution in experimental systems relevant to tissue homeostasis and disease-associated stress responses.This Apolipoprotein J antibody complements a related Clusterin antibody used to study CLU, APO-J, and Apolipoprotein J biology.