Anti-CLSPN

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA026305.25	25 µl		-		7 - 10 business days*		246.00€
ATA-HPA026305.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Required for checkpoint mediated cell cycle arrest in response to inhibition of... more

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Product information "Anti-CLSPN"

Protein function: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 85% and to rat: 87%

Keywords:	Anti-CLSPN, Anti-Claspin, Anti-hClaspin
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA026305

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: SFVILEPETN RELEALKQRF WKHANPAAKP RAGQTVNVNV IVKDMGTDGK EELKADVVPV TLAPKKLDGA SHTKPGEKLQ VLKAKLQEAM KLRR (ATA-APrEST90640)