Anti-CLPS / Colipase, clone CLPS/12806R

1 mg/ml in 1X PBS, BSA free, sodium azide free. Colipase (CLPS) is a pancreatic secreted protein that functions as an essential cofactor for pancreatic lipase, enabling efficient digestion of dietary lipids in the small intestine. CLPS Antibody is widely used to study this protein in pancreatic tissue and digestive systems, where it is produced by acinar cells and secreted into the gastrointestinal tract to support lipid hydrolysis and nutrient absorption.The CLPS Antibody / Pancreatic Digestive Enzyme Marker is designed to detect Colipase in pathways associated with exocrine pancreatic function and digestive enzyme activity. CLPS antibody, also referred to as Colipase antibody or pancreatic colipase antibody in the literature, enables identification of this protein in tissue and lysate-based assays where characterization of digestive enzyme systems is required. Its restricted expression in pancreatic acinar cells makes it a highly specific marker of exocrine pancreas biology.Functionally, Colipase binds pancreatic lipase and facilitates its interaction with lipid substrates in the presence of bile salts, stabilizing the enzyme at the lipid-water interface. This interaction is critical for efficient triglyceride breakdown and absorption of fatty acids. CLPS Antibody is therefore valuable for studying digestive physiology, enzyme regulation, and pancreatic exocrine function in both normal and disease contexts.CLPS is primarily expressed in pancreatic acinar cells, where it is synthesized, processed, and secreted into the digestive tract. In immunohistochemistry, this is reflected by strong cytoplasmic staining in acinar structures, consistent with protein production and secretion. Minimal expression is typically observed in non-pancreatic tissues, reinforcing its specificity as a pancreatic marker.Subcellularly, Colipase is synthesized in the endoplasmic reticulum and processed through the secretory pathway prior to release. In western blot analysis, CLPS is detected as a relatively low molecular weight protein consistent with its mature secreted form. Detection across pancreatic and related tissue lysates provides insight into protein expression levels and secretion dynamics.This CLPS Antibody is supported by western blot data demonstrating detection of Colipase in relevant tissue lysates, along with immunohistochemistry data showing strong staining in pancreatic tissue consistent with known expression patterns. Together, these features support its use in studies of digestive enzyme biology, pancreatic function, and lipid metabolism.This antibody is part of a broader antibody panel offered by NSJ Bioreagents.