Anti-CLIC4 / Chloride intracellular channel protein 4, clone 30C24

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.. CLIC4 antibody targets chloride intracellular channel protein 4, a member of the CLIC family of proteins that function as intracellular chloride channels and signaling modulators. Unlike classical ion channels, CLIC4 can exist in both soluble and membrane-associated forms, transitioning between states to regulate chloride conductance. This protein is expressed across many tissues, including endothelial cells, immune cells, and epithelial cells, where it contributes to processes such as apoptosis, angiogenesis, and cellular stress responses.Research using CLIC4 antibody has demonstrated its involvement in multiple pathological processes. CLIC4 is frequently upregulated during tissue remodeling and fibrotic diseases, where it influences transforming growth factor-beta (TGF-beta) signaling pathways. It has also been studied in the context of cancer, with evidence suggesting that CLIC4 contributes to tumor progression and metastasis through regulation of cell migration and invasion. In immune biology, CLIC4 has been implicated in the modulation of macrophage activation and inflammatory responses.Validated clones for CLIC4 detection perform well in assays including western blot, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to monitor subcellular localization, expression changes under stress conditions, and signaling outcomes tied to chloride channel activity. The versatility of CLIC4 in both membrane transport and cell signaling makes it a protein of interest in diverse fields of study.NSJ Bioreagents offers this CLIC4 antibody to support investigations in cancer biology, fibrosis, and cellular signaling. Alternate names include chloride intracellular channel protein 4 antibody, CLIC4A antibody, MSTP046 antibody, HuH1 antibody, and DKFZp564F012 antibody.