Anti-CLDN11 / Claudin 11

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. CLDN11 antibody detects Claudin-11, encoded by the CLDN11 gene on chromosome 3q26.2. CLDN11 antibody is widely used in studies of tight junctions, myelination, and testis biology. Claudin-11 belongs to the claudin family of integral membrane proteins that form tight junction strands, regulating paracellular permeability and barrier functions. Unlike other claudins primarily expressed in epithelial tissues, CLDN11 is highly expressed in oligodendrocytes and Sertoli cells, where it plays unique roles in central nervous system myelin formation and in maintaining the blood-testis barrier.Structurally, Claudin-11 is a ~23 kDa tetraspan membrane protein with two extracellular loops and a short cytoplasmic tail. These extracellular loops mediate homotypic and heterotypic interactions with claudins on adjacent cells, forming tight junction strands. Its C-terminal PDZ-binding motif recruits cytoplasmic scaffolding proteins such as ZO-1, linking junctions to the cytoskeleton.Functionally, CLDN11 is essential for central nervous system function and fertility. In oligodendrocytes, it contributes to formation of myelin sheaths by establishing tight junctions that compartmentalize paranodal regions. In the testis, CLDN11 maintains the blood-testis barrier, supporting spermatogenesis by protecting germ cells from immune responses. Knockout mice lacking CLDN11 develop neurological deficits and male infertility, confirming its physiological importance. Researchers use CLDN11 antibody to study tight junction biology, myelin structure, and reproductive physiology.Clinically, altered CLDN11 expression is linked to neurological disorders and infertility. Deficiency causes defects in myelination, contributing to tremors and motor dysfunction. In humans, CLDN11 has been implicated in demyelinating diseases and some forms of male infertility. Dysregulation of claudin proteins is also studied in cancer, where barrier integrity is often disrupted. NSJ Bioreagents provides CLDN11 antibody as a reliable reagent for neuroscience, fertility, and cancer research.Experimentally, CLDN11 antibody is applied in immunohistochemistry to study oligodendrocytes and seminiferous tubules, in western blotting to detect the ~23 kDa protein, and in immunofluorescence microscopy to analyze tight junction distribution. Electron microscopy combined with CLDN11 antibody staining reveals detailed structural organization of tight junctions in myelin and testes.