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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES17381.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES17381.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded... more
Product information "Anti-CLCN3"
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011], Protein function: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: [Isoform 1]: Early endosome membrane , Multi-pass membrane protein . Late endosome membrane , Multi-pass membrane protein . Lysosome membrane , Multi-pass membrane protein . Cell membrane , Multi-pass membrane protein . Isoform 1 is localized mainly in late endosomes. ., [Isoform 2]: Golgi apparatus membrane , Multi-pass membrane protein . Cell projection, ruffle membrane , Multi-pass membrane protein . Isoform 2 is mainly enriched in the Golgi (PubMed:12471024). Colocalizes with SLC9A3R1/EBP50 in membrane ruffles (PubMed:11967229). .
Keywords: | Anti-CLCN3, Anti-ClC-3, Anti-Chloride transporter ClC-3, Anti-Chloride channel protein 3, Anti-H(+)/Cl(-) exchange transporter 3, CLCN3 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES17381 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthesized peptide derived from human CLCN3 AA range: 597-647 |
Format: | Purified |
Database Information
KEGG ID : | K05012 | Matching products |
UniProt ID : | P51790 | Matching products |
Gene ID | GeneID 1182 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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