Anti-Claudin 4, clone YN00506m

Claudin4, a member of the tight junction protein family, is mainly distributed in the cell membrane and cytoplasm of the epithelial cells of the intestinal cavity in normal tissues. It is mainly distributed in the cell membrane in adenomas and in the cell membrane in colorectal cancer. The highest expression was observed in adenomas. Claudin-4 has been shown to distinguish adenocarcinoma from malignant mesothelioma with 99% specificity in malignant effusions. In multivariate analysis of breast cancer, Claudin-4 overexpression was able to independently predict survival, as it was associated with poor prognosis, high tumor grade, and Her2 expression, and was inversely associated with estrogen receptor staining. Protein function: Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (PubMed:36008380). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (PubMed:35773259, PubMed:36008380). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance (PubMed:35773259, PubMed:36008380). Cannot form tight junction strands on its own (PubMed:35773259, PubMed:36008380). [The UniProt Consortium]