Anti-CKII alpha (IHC)

Anti-CKII alpha (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00036-T 10 µl (5+ slides) -

6 - 10 business days*

131.00€
IHC-00036 100 µl (50+ slides) -

6 - 10 business days*

493.00€
 
Protein function: Catalytic subunit of a constitutively active serine/threonine-protein kinase... more
Product information "Anti-CKII alpha (IHC)"
Protein function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). [The UniProt Consortium]
Keywords: Anti-CK2A1, Anti-CSNK2A1, Anti-CK II alpha, EC=2.7.11.1, Anti-Casein kinase II subunit alpha
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00036

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, Tasmanian Devil, White-tufted-ear Marmoset, African Elephant, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00036 maps to a region between residue 300 and 350 of human Casein Kinase 2, alpha 1 using the numbering given in entry NP_001886.1 (GeneID 1457).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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