Anti-Citrullinated Fibrinogen (Clone 10E9.3)

Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis. It is comprised of two sets of Aalpha, Bbeta, and gamma polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans. Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aalpha and Bbeta chains, yielding the alpha and beta chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots. Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia. Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease. Fibrinogen can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4. Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis. Cayman's Citrullinated Fibrinogen Monoclonal Antibody (Clone 10E9.3) can be used for ELISA and Western blot (WB) applications. The antibody recognizes citrullinated fibrinogen at 56 kDa from human samples.Immunogen: Human citrullinated fibrinogen. Clone Designation: 10E9.3. MW: 56 kDa. Formulation: (Request formulation change), 100 µg of protein G-purified antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG2b. Applications: ELISA, WB. Cross Reactivity: (-) Human Fibrinogen.