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The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. Protein function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. [The UniProt Consortium]
Keywords:
Anti-CISD2, Anti-NAF-1, Anti-CDGSH2, Anti-Miner1, Anti-MitoNEET-related 1 protein, Anti-Nutrient-deprivation autophagy factor-1, Anti-CDGSH iron-sulfur domain-containing protein 2, Anti-Endoplasmic reticulum intermembrane small protein, CISD2 Polyclonal A
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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