Protein function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. [The UniProt Consortium]
Anti-HCC1, Anti-SARNP, Anti-HSPC316, Anti-Nuclear protein Hcc-1, Anti-Cytokine-induced protein of 29 kDa, Anti-SAP domain-containing ribonucleoprotein, Anti-Proliferation-associated cytokine-inducible protein CIP29
synthetic peptide. The epitope recognized by A303-209A-T maps to a region between residue 1 and 50 of human Cytokine-Induced Protein of 29 kDa using the numbering given in entry NP_149073.1 (GeneID 84324).