Anti-Chromogranin A (Neuroendocrine Marker), clone SPM553

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Cytoplasmic vesicle, Neuronal dense core vesicle, Secreted, Secretory vesicle. Positive Control: bowel, pancreas or pheochromocytoma., PC12 cells. Adrenal gland, Thyroid. Chromosome Location: 14q32.12. Protein Function: Strongly inhibits glucose induced insulin release from the pancreas , Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522) , Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation [The Uniprot Consortium]