Anti-CHD4, clone 3F2/4

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Centrosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Nucleus. Positive Control: HeLa whole cell lysate or human placenta tissue lysate. Human breast carcinoma. Chromosome Location: 12p13.31. Protein Function: ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity) [The Uniprot Consortium]