Anti-CEP55

Centrosomal protein of 55 kDa is a protein that in humans is encoded by the CEP55 gene. CEP55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9, the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT, the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP, the interaction is direct, CEP55 binds PDCD6IP in a 2:1 stoechiometry, PDCD6IP competes with TSG101 for the same binding site. Protein function: Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). [The UniProt Consortium]