Anti-CENP-F/Mitosin (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00315-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00315 100 µl (50+ slides) -

3 - 9 business days

470.00€
 
Protein function: Required for kinetochore function and chromosome segregation in mitosis.... more
Product information "Anti-CENP-F/Mitosin (IHC)"
Protein function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. [The UniProt Consortium]
Keywords: Anti-CENPF, Anti-CENP-F, Anti-Mitosin, Anti-AH antigen, Anti-Centromere protein F, Anti-Kinetochore protein CENPF
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00315-T

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Gorilla, Chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00315 maps to a region between residue 2350 and 2400 of human centromere protein F (Mitosin) using the numbering given in entry AAA82889.1 (GeneID 1063).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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