Anti-CELA3A / Chymotrypsin like elastase 3A, clone CELA3A/12553

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. CELA3A antibody targets Chymotrypsin like elastase 3A, a digestive serine protease encoded by the CELA3A gene and primarily produced by pancreatic acinar cells. Chymotrypsin like elastase 3A is synthesized as an inactive zymogen and stored in secretory granules, then released into the intestinal lumen where it participates in protein digestion. CELA3A is predominantly localized to the cytoplasmic secretory compartment of pancreatic acinar cells and is a well-established marker of exocrine pancreatic tissue.Functionally, Chymotrypsin like elastase 3A catalyzes the cleavage of peptide bonds in dietary proteins, contributing to efficient digestion and nutrient absorption. A short functional summary is that CELA3A supports normal digestive enzyme activity in the gastrointestinal tract as part of the pancreatic elastase family. Through its proteolytic activity, CELA3A plays an essential role in exocrine pancreatic function and digestive physiology.At the molecular level, CELA3A belongs to the trypsin-like serine protease family and contains the conserved catalytic triad required for protease activity. Activation occurs through proteolytic processing in the intestinal environment. CELA3A antibody reagents are therefore useful for studying pancreatic enzyme expression, acinar cell differentiation, and regulation of digestive protease production. Clone CELA3A/12553 is designed to recognize Chymotrypsin like elastase 3A and supports consistent detection of CELA3A expression in research applications.From a biological and disease relevance perspective, CELA3A expression is commonly used as a marker of pancreatic acinar cell identity and exocrine differentiation. Altered expression of Chymotrypsin like elastase 3A has been examined in pancreatic injury, pancreatitis, and pancreatic cancer, where loss of acinar markers may reflect cellular dedifferentiation or disease progression. CELA3A antibody tools are valuable for distinguishing acinar-derived cells from ductal or endocrine cell populations in pancreatic tissue studies.Developmentally, CELA3A expression increases with maturation of the exocrine pancreas and acquisition of digestive function. Clone CELA3A/12553 provides a reliable reagent for detecting Chymotrypsin like elastase 3A in studies of pancreatic biology, digestive enzyme regulation, and gastrointestinal disease. CELA3A antibodies from NSJ Bioreagents are supplied for research use to support investigations in pancreatic physiology and pathology.