Anti-ceh-14

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1 and homeobox protein ceh-63, perhaps acting in concert with ceh-63 (PubMed:22207033). Binds to a motif including the sequence 5'-CTAAT-3' in regulatory promoter elements (PubMed:25614239). Confers thermosensory function to neurons (PubMed:10774727). Required for correct AFD-mediated thermotaxis (PubMed:10774727). In concert with homeobox protein ttx-1, perhaps as components in a complex, specifies identity of AFD neurons, acting by synergistically regulating receptor-type guanylyl cyclase gcy-8, gcy-18 and other genes (PubMed:25614239). Involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA (PubMed:20501595). Regulates its own expression and also that of homeodomain ceh-17, together forming an autoregulatory loop in the ALA neuron (PubMed:20501595, PubMed:26096732). Required for initial pathfinding of the ALA axons, but largely dispensable for axon migration (PubMed:20501595). Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein lim-6, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT (PubMed:12490565). Plays a role in controlling the peptidergic identity of the BDU neurons, regulating expression of flp-10, nlp-1, and nlp-15, thereby modulating the harsh touch response (PubMed:26096732). [The UniProt Consortium]