Anti-CEACAM6 / Carcinoembryonic antigen-related cell adhesion molecule 6, clone CEACAM6/13371R

1 mg/ml in 1X PBS, BSA free, sodium azide free. CEACAM6 antibody (clone CEACAM6/13371R) targets Carcinoembryonic Antigen Related Cell Adhesion Molecule 6, a glycosylphosphatidylinositol-anchored cell surface glycoprotein encoded by the human CEACAM6 gene. CEACAM6, also widely referred to as CD66c in immunology literature, is a member of the carcinoembryonic antigen related cell adhesion molecule family involved in intercellular adhesion and immune regulation. CEACAM6 antibody is commonly used in studies of epithelial biology, tumor progression, and inflammatory signaling because CEACAM6 expression is frequently elevated in multiple carcinomas.CEACAM6 is localized to the plasma membrane via a GPI anchor and mediates homophilic and heterophilic cell-cell interactions. In normal tissues, CEACAM6 is expressed on granulocytes and certain epithelial cells, including those of the gastrointestinal and respiratory tracts. Overexpression of CEACAM6 has been reported in colorectal, pancreatic, gastric, breast, and lung cancers, where it has been associated with tumor cell adhesion, invasion, and resistance to apoptosis. CEACAM6 antibody clone CEACAM6/13371R supports detection of CEACAM6 expression in epithelial tumors and immune cell populations in research applications.Functionally, CEACAM6 participates in signaling pathways that influence cell survival, proliferation, and metastatic potential. Increased CEACAM6 expression has been linked to enhanced tumor cell motility and reduced anoikis sensitivity, contributing to cancer progression. Because of its cell surface localization and tumor-associated overexpression, CEACAM6 antibody is frequently applied in cancer biology and translational oncology research.Structurally, CEACAM6 contains immunoglobulin-like extracellular domains characteristic of the CEACAM family and lacks a transmembrane domain due to its GPI anchorage. A CEACAM6 antibody such as clone CEACAM6/13371R is suitable for detecting CEACAM6 expression in epithelial tissues and tumor specimens in research settings.