Anti-CDK5RAP3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40022.100	100 µl		-	-	10 - 15 business days*		707.00€

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Protein function: Probable tumor suppressor initially identified as a CDK5R1 interactor... more

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Product information "Anti-CDK5RAP3"

Protein function: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). [The UniProt Consortium]

Keywords:	Anti-MSTP016, Anti-Protein HSF-27, Anti-CDK5 activator-binding protein C53, Anti-CDK5 regulatory subunit-associated protein 3, Anti-LXXLL/leucine-zipper-containing ARF-binding protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40022

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant fusion protein corresponding to aa. 1-300 of Human CDK5RAP3 (NP_788276.1)
MW:	57 kD
Format:	Affinity Purified