Anti-CDC27

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-62662.60 60 µl - -

7 - 16 business days*

117.00€
E-AB-62662.120 120 µl - -

7 - 16 business days*

208.00€
E-AB-62662.200 200 µl - -

7 - 16 business days*

363.00€
 
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein... more
Product information "Anti-CDC27"
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. Protein function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. [The UniProt Consortium]
Keywords: Anti-APC3, Anti-CDC27, Anti-H-NUC, Anti-ANAPC3, Anti-CDC27Hs, Anti-CDC27 homolog, Anti-Anaphase-promoting complex subunit 3, Anti-Cell division cycle protein 27 homolog, CDC27 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-62662

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human CDC27

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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