Anti-Cdc20, clone CDC20/1102

Anti-Cdc20, clone CDC20/1102
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3041SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Cyclins, regulatory subunits, which... more
Product information "Anti-Cdc20, clone CDC20/1102"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested. Protein function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. [The UniProt Consortium]
Keywords: Anti-CDC20, Anti-p55CDC, Anti-Cell division cycle protein 20 homolog, Cdc20 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3041SAF-100UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: CDC20/1102
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human Cdc20 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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