Anti-CDC2

Anti-CDC2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030070.100 100 µl - -

3 - 19 business days*

477.00€
 
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or... more
Product information "Anti-CDC2"
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration. Applications: Western Bloting: 1:500-1:2000., Immunohistochemistry: 1:200-1:1000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-CDK1, Anti-CDC2, EC=2.7.11.23, EC=2.7.11.22, Anti-p34 protein kinase, Anti-Cyclin-dependent kinase 1, Anti-Cell division protein kinase 1, Anti-Cell division control protein 2 homolog
Supplier: United States Biological
Supplier-Nr: 030070

Properties

Application: ELISA, IHC, WB
Antibody Type: Monoclonal
Clone: 13B148
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant fragment of CDC2 expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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