Anti-CD99

CD99,also known as MIC2,is a heavily O-glycosylated transmembrane protein involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. CD99 is broadly distributed on many cell types,with particularly strong expression on human cortical thymocytes,Ewing's sarcoma cells and peripheral primitive neuroectodermal tumors . In normal cells,CD99 has been functionally implicated in cell adhesion,migration,apoptosis,differentiation,activation,and proliferation of lymphocytes and monocyte extravasation and transport of several transmembrane proteins . CD99 displays two surface isoforms generated by alternative splicing: a long 32 kDa and a short 28 kDa form . Protein function: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes. [The UniProt Consortium]