Anti-CD95 / FAS / TNFRSF6, clone B-R18

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cell membrane, Membrane raft, Secreted. Positive Control: MCF-7 cells (IF/FACS). Human hepatocellular or bladder carcinoma (IHC). Chromosome Location: 10q24.1. Protein Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) [The Uniprot Consortium]