Anti-CD8a Cocktail, clone C8/468 + C8/144B

Anti-CD8a Cocktail, clone C8/468 + C8/144B
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3134IHC-7ML 7 ml - -

3 - 10 business days

Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. CD8 is... more
Product information "Anti-CD8a Cocktail, clone C8/468 + C8/144B"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8a/b) or as a homodimer (CD8a/a). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. Protein function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. [The UniProt Consortium]
Keywords: Anti-MAL, Anti-CD8a, Anti-CD8A, Anti-T-cell surface glycoprotein CD8 alpha chain, Anti-T-lymphocyte differentiation antigen T8/Leu-2, CD8a Antibody Cocktail
Supplier: NSJ Bioreagents
Supplier-Nr: V3134IHC-7ML


Application: IHC
Antibody Type: Mixed
Clone: C8/468 + C8/144B
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human recombinant protein (C8/468) and 13 amino acid peptide from the C-terminal cytoplasmic domain of the alpha chain of human CD8 (C8/144B) were used as the immunogens for this CD8a antibody cocktail.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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